biology genomics single-cell model_cls_name:SCVI scvi_version:0.20.0 anndata_version:0.8.0 modality:rna annotated:False

Description

scVI model trained on the full DLPFC Visium data (including the pilot samples).

Model properties

Many model properties are in the model tags. Some more are listed below.

model_init_params:

{
    "n_hidden": 128,
    "n_latent": 5,
    "n_layers": 1,
    "dropout_rate": 0.1,
    "dispersion": "gene",
    "gene_likelihood": "zinb",
    "latent_distribution": "normal"
}

model_setup_anndata_args:

{
    "layer": "counts",
    "batch_key": "patient",
    "labels_key": null,
    "size_factor_key": null,
    "categorical_covariate_keys": [
        "sample",
        "study"
    ],
    "continuous_covariate_keys": null
}

model_summary_stats:

Summary Stat Key Value
n_batch 13
n_cells 166443
n_extra_categorical_covs 2
n_extra_continuous_covs 0
n_labels 1
n_vars 5000

model_data_registry:

Registry Key scvi-tools Location
X adata.layers['counts']
batch adata.obs['_scvi_batch']
extra_categorical_covs adata.obsm['_scvi_extra_categorical_covs']
labels adata.obs['_scvi_labels']

model_parent_module: scvi.model

data_is_minified: False

Training data

This is an optional link to where the training data is stored if it is too large to host on the huggingface Model hub.

<!-- If your model is not uploaded with any data (e.g., minified data) on the Model Hub, then make sure to provide this field if you want users to be able to access your training data. See the scvi-tools documentation for details. -->

Training data url: N/A

Training code

This is an optional link to the code used to train the model.

Training code url: N/A

References

  1. Maynard, Kristen R., et al. "Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex." Nature neuroscience 24.3 (2021): 425-436.
  2. Huuki-Myers, Louise A., et al. "Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex." BioRxiv (2023): 2023-02.